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Well-differentiated liposarcoma

3 associated genes
4 signs/symptoms

PROTEIN INTERACTIONS: 2

Isolated polycystic liver disease

1 OMIM reference -
2 associated genes
14 signs/symptoms

Well-differentiated liposarcoma

Isolated polycystic liver disease

CDK4	(UniProt - OMIM)		PRKCSH	(UniProt - OMIM)
HMGA2	(UniProt - OMIM)		SEC63	(UniProt - OMIM)
MDM2	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	MDM2 MDM2	(0.63) (0.49)	PRKCSH SEC63

Citations in the biomedical literature:

Well-differentiated liposarcoma		Isolated polycystic liver disease
	Synonym(s): - ALT - Atypical lipoma - Atypical lipomatous tumor - WDLS		Synonym(s): - ADPCLD - Autosomal dominant polycystic liver disease - PCLD

	Classification (Orphanet): - Rare oncologic disease		Classification (Orphanet): - Rare genetic disease - Rare hepatic disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: unknown Average age onset: adulthood Average age of death: adult Type of inheritance: sporadic		Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: adulthood Average age of death: normal Type of inheritance: autosomal dominant

	External references: No OMIM references No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: C536330

Well-differentiated liposarcoma		Isolated polycystic liver disease
	Very frequent - Soft tissue sarcoma / cancer / tumor / liposarcoma / myosarcoma - Subcutaneous nodules / lipomas / tumefaction / swelling Occasional - Functional anomalies of the kidney and the urinary tract - Intestinal transit disorder		Very frequent - Autosomal dominant inheritance - Hepatomegaly / liver enlargement (excluding storage disease) - Polycystic liver disease / hepatic cysts Frequent - Polycystic kidneys Occasional - Acute abdominal pain / colic - Arterial aneurism (excluding aorta) - Early death / lethality - Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia - Gastroesophageal reflux / pyrosis / esophagitis / hiatal hernia / gastroparesia - Gastrointestinal bleeding / hemorrhage / hematemesis / melena / rectorrhagia - Hepatitis / icterus / cholestasis - Respiratory distress / dyspnea / respiratory failure / lung volume reduction - Structural anomalies of the pancreas - Structural anomalies of the respiratory system and diaphragm